There was a lot of interest, particularly in the 1990s, in hemoglobin-based oxygen carriers (HBOCs) as a substitute for blood transfusions. HBOCs eliminate the need for cross-matching prior to use, they don’t require refrigeration, and they have a longer shelf life than banked blood. However, these cell-free hemoglobin oxygen substitutes have been shown to be […]
For more than ten years, the Society of Cardiovascular Anesthesiologists (SCA) has realized the need to make quality and safety a priority. Dr. Atilio Barbeito, Department of Anesthesiology, Duke University Medical Center, Veterans Affairs Medical Center, Durham, North Carolina, and colleagues from throughout the United States describe the SCA’s 10-year effort to improve patient safety […]
Patients with severe aortic stenosis (AS) may be old, frail, have significant comorbidities, and have by definition have highly compromised ventricular function. They may also have had previous cardiac surgery. These risk factors may place the patient at inordinate risk from conventional aortic valve replacement (AVR). Transcatheter aortic valve replacement (TAVR) is potentially far less […]
Heart failure affects more than five million Americans and is one of the major causes of hospitalization in patients over 65 years of age. The number of patients with chronic heart failure will increase as Americans live longer. Additionally, patients with heart failure are living longer through medical advances. As we age, the chance of […]
Blood administration is not without risk. Antifibrinolytic agents are used to control bleeding and blood product administration. In particular, aprotinin has been shown to have adverse effects. In one study comparing aprotinin to tranexamic acid or aminocaproic acid in patients undergoing high-risk cardiac surgery, the trial was ended early because of a high death […]
Cardiopulmonary bypass, autologous, and allogeneic blood: how do they affect red blood cell deformability and aggregation?
Blood delivers oxygen to the body’s tissues. Wine may improve from aging, but oxygen delivery capacity of blood decreases with age. Oxygen delivery of blood is related to the quality of the red cell membrane. As the membrane stiffens, the cell become less deformable, and less readily traverses small capillary vascular beds. As it ages, […]