cardiac surgery

Can dexamethasone reduce delirium incidence after cardiac surgery?

Can dexamethasone reduce delirium incidence after cardiac surgery?

Delirium is seen in at least 50% of patients after cardiac surgery. Patients with delirium have a greater likelihood extended hospital stay, long-term cognitive impairment, and death after surgery. Cardiac surgery and cardiopulmonary bypass trigger an inflammatory response. This response may contribute to neuroinflammation, brain injury, and postoperative delirium. Steroids may decrease neuroinflammation and the […]

Studies of MDCO-2010, a drug that could have potentially replaced TXA or aprotinin

Studies of MDCO-2010, a drug that could have potentially replaced TXA or aprotinin

  Blood administration is not without risk.  Antifibrinolytic agents are used to control bleeding and blood product administration.  In particular, aprotinin has been shown to have adverse effects.  In one study comparing aprotinin to tranexamic acid or aminocaproic acid in patients undergoing high-risk cardiac surgery, the trial was ended early because of a high death […]